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Oral Use: Dissolve the granules in about ½ glass of water, avoiding the addition of drugs to the solution and taking it before or after meals.
Adults: Acute Treatment: 1 sachet of 200 mg or 2 sachets of 100 mg 3 times daily for 5-10 days.
Chronic Treatment: 1 sachet of 200 mg 2-3 times or 1 effervescent tablet daily for a period of 6 months to obtain the maximum benefit eg, in the prevention of chronic bronchitis excubation. But substantial symptomatic improvement is usually already noticeable in 1-2 months.
Children: Acute Treatment: Up to 2 years: ½ sachet of 200 mg or 1 sachet of 100 mg; from 2-6 years: 1 sachet of 200 mg or 2 sachets of 100 mg 2 times daily for 5-10 days.
Mucoviscidosis: Up to 2 years: 50 mg 3 times daily; from 2-6 years: 100 mg 3 times daily.
Local Therapy: Unless otherwise prescribed:
Aerosol Therapy: Adults: 1 amp/session 1-2 times a day. Children: ½ amp 1-2 times a day.
Endobronchial Instillations: Adults: ½-1 amp 1-2 times a day. Children: ¼-½ amp 1-2 times a day.
Intranasal Installation: Adults: 3-5 drops/instillation.
Intra-Auricular and Intranasal Instillation: Children: 2-3 drops/instillation.
Intrasinusal Instillation: Adults: ½-1 amp/instillation.
For aerosol therapy, the use of devices with glass or plastic parts is preferred. If devices with metal or rubber parts are used, these should be rinsed out with water immediately after use.
Parenteral Therapy:
IM Therapy: Adults: 1 amp injected 1-2 times a day (deep IM).
Children: Pre-school: Aerosol therapy should be given preference.
School Age: In general, inject ½ amp 1-2 times daily.
Since a slight, transient burning sensation can occur with superficial injection in persons with increased sensitivity, it is recommended that patients be given deep IM injection while lying in a relaxed position.
IV Therapy: As Mucolytic:
Normal Therapy: Adults: 1 amp 1-2 times a day, slowly IV.
Children: ½ amp 1-2 times a day slowly IV.
Intensive Therapy: Adults: 2-3 amps 2-3 times a day slowly IV.
Children: 1-1 ½ amp 2-3 times a day slow IV.
The 1st dose should be diluted with an equal volume of a 0.9% NaCl solution or a 5% glucose solution. The following doses should be used as infusions:
As antidote:
In the treatment of acetaminophen, acrylonitrile, methacrylonitrile and methyl bromide poisoning, Fluimucil/A antidote is available in vials containing 25 mL of 20% injection solution.
Suggested Dose for Antidote Therapy: Within the first 15 min, 150 mg/kg, without dilution, by slow direct IV injection. After 15 min and up to 4 hrs, as in infusion, 50 mg/kg, with 500 mL of 5% glucose solution.
The duration of treatment depends on the clinical picture. It generally lasts 1-2 weeks. Since Fluimucil/A causes no toxic side effects, the recommended dose can be exceeded if necessary.
