Etoposide Teva Drug Interactions

The occurrence of acute leukaemia, which can occur with or without a preleukemic phase, has been reported rarely in patients treated with etoposide in association with other antineoplastic drugs such as bleomycin, cisplatin, ifosfamide and methotrexate.
Note: The ready-for-use IV solution should not be physically mixed with any other drug.
Etoposide/Vaccines, killed virus: Because normal defense mechanisms may be suppressed by etoposide therapy, the patient's antibody response to the vaccine may be decreased. The interval between discontinuation of medications that cause immunosuppression and restoration of the patient's ability to respond to the vaccine depends on the intensity and type of immunosuppression-causing medication used, the underlying disease, and other factors; estimates vary from 3 months to 1 year.
Etoposide/Vaccines, live virus: Because normal defense mechanisms may be suppressed by etoposide therapy, concurrent use with a live virus vaccine may potentiate the replication of the vaccine virus, may increase the adverse effects of the vaccine virus, and/or may decrease the patient's antibody response to the vaccine; immunization of these patients should be undertaken only with extreme caution after careful review of the patient's hematologic status and only with the knowledge and consent of the physician managing the etoposide therapy. The interval between discontinuation of medications that cause immunosuppression and restoration of the patient's ability to respond to the vaccine depends on the intensity and type of immunosuppression-causing medication used, the underlying disease, and other factors; estimates vary from 3 months to 1 year. Patients with leukemia in remission should not receive live virus until at least 3 months after their last chemotherapy. In addition, immunization with oral polio-virus vaccine should be postponed in persons in close contact with the patient, especially family members.