Etoposide Teva Caution For Usage

Pharmaceutical Precautions: Incompatibilities: The ready-for-use IV solution should not be physically mixed with any other drug.
Dilution of Etoposide for Injection Concentrate: Etoposide for Injection Concentrate may be diluted with either 5% Dextrose Injection, or 0.9% Sodium Chloride Injection, to give a final concentration of 0.2 mg/ml. The dilutions of Etoposide For Injection Concentrate in 5% Dextrose Injection, or 0.9% Sodium Chloride Injection are stable for 120 hours. Etoposide should not be physically mixed with any other drug. Any solution showing signs of precipitation should be discarded. (See also Dosage & Administration.)
Handling and Disposal: As with all cytotoxic preparations, special precautions should be taken for safe handling and disposal.
1. Only trained personnel should handle the drug. Pregnant women should not be involved in the handling process.
2. Handling should be performed in a designated area, ideally in a vertical laminar flow hood (Biological Safety Cabinet - Class II). The work surface should be covered with disposable plastic-backed absorbent paper.
3. Adequate protective clothing should be worn, i.e. PVC gloves, safety glasses, disposable gowns and masks. In the event of contact with the eyes, wash with copious amounts of water or saline.
4. Luer-Lock fittings should be used on all syringes and sets. The possible formation of aerosols may be reduced by using large bore needles and venting needles.
5. AII unused material, needles, syringes, vials and other items which have come into contact with cytotoxic drugs, should be segregated, placed in double sealed polyethylene bags and incinerated at 1000°c or more. Excreta should be similarly treated. Liquid waste may be flushed away with copious amounts of water.