DIVATOR contains atorvastatin calcium equivalent to 10 or 20 mg of the active ingredient atorvastatin.
Excipients/Inactive Ingredients: calcium carbonate, microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, polysorbate 80, hydroxypropyl cellulose and magnesium stearate.
DIVATOR belongs to a group of medicines known as lipid regulating medicines (of the type commonly known as statins).
DIVATOR is used in adults and children aged 10 years and above to lower fats known as cholesterol and triglycerides in the blood when a low fat diet and other non-medicinal treatments such as exercise and lifestyle changes have failed.
If the patient is diabetic and has at least one other risk factor for cardiovascular disease, DIVATOR reduces the risk of having a major cardiovascular event such as a heart attack or stroke.
The usual starting dose of DIVATOR is 10 mg once a day in adults and children aged 10 years and above. This may be increased if necessary by the doctor until the patient is taking exactly the amount needed. DIVATOR tablet should be swallowed, and can be taken at any time of day, with or without food. Do not drink more than one or two small glasses of grapefruit juice per day. Remember to continue with diet and lifestyle changes while taking DIVATOR.
Missed dose: If a dose is forgotten to take, take it as soon as remembered unless it is time for the next dose.
Do not take 2 doses at the same time.
If too many DIVATOR tablets are accidently taken, tell the doctor at once. If this cannot be done, go to the nearest hospital accident and emergency department. Take along any tablets that are left, the container and the label so that the hospital staff can easily tell what medicine has been taken.
Do not take DIVATOR if the patient: Is a woman able to have children not using adequate contraceptive measures; Is pregnant, trying to become pregnant or breast-feeding; Has ever had a reaction to DIVATOR or to any similar medicines used to lower blood lipids or to any of the inactive ingredients of the medicine; Has or has had a disease which affects the liver and any unexplained abnormal blood tests for liver function; Drinks excessive amounts of alcohol that might be affecting the liver; Has intolerance to some sugars.
Talk to the doctor or pharmacist at once.
The doctor will need to carry out a blood test before and possibly during DIVATOR treatment if the patient experiences any of the following: kidney problems, underactive thyroid gland (hypothyroidism), any muscle disorders (affecting either the patient or members of the patient's family), previous muscular problems during treatment with other lipid-lowering medicines (e.g. other "-statin" or "-fibrate" medicines), or a history of heavy alcohol consumption.
These blood tests will be used to predict the patient's risk of muscle-related side effects.
It is recommended that liver function tests should be performed before the initiation of DIVATOR, and thereafter when clinically indicated.
Use in Elderly: A blood test may also be required if the patient is older than 70 years in order to determine the risk of muscle-related side effects.
If the patient is trying to become pregnant, the doctor will advise to stop taking DIVATOR about one month before planning to conceive.
As with all medicines, DIVATOR can sometimes cause side-effects in some individuals. The most commonly reported ones are: Nausea, abdominal pain, constipation, wind, indigestion, headache, muscle pain, weakness, diarrhoea and insomnia.
Other less common side-effects have been seen in some patients taking DIVATOR or other medicines of this kind. Not all of these effects have necessarily been linked to the use of these medicines. These include: Muscle cramps, weakness or tenderness, numbness or tingling in the fingers and toes, impotence, pancreatitis (inflammation of the pancreas leading to stomach pain), hepatitis (liver inflammation), jaundice (yellowing of the skin and whites of the eyes), loss of appetite, vomiting, hair loss, itching, rash (rarely severe blistering rash with associated general illness), chest pain, dizziness, allergic reactions, joint pain, loss of memory, back pain, weight gain, oedema (e.g. ankle swelling), feeling tired, noises in the ears and/or head, reduction in sensation of skin to light, touch or pain.
Angioneurotic oedema (swelling of the face, tongue and windpipe which can cause great difficulty in breathing). This is a very rare reaction which can be serious if it occurs. The patient should tell the doctor immediately if it happens.
Rarely, patients have developed muscle wasting or inflammation, and very rarely this has progressed to become a serious potentially life-threatening condition (called "rhabdomyolysis"). If having muscle weakness, tenderness or pain and particularly at the same time, feeling unwell or having a high temperature, stop taking DIVATOR and tell the doctor immediately. Consult the doctor as soon as possible if experiencing symptoms suggestive of liver complaint (see Contraindications).
Abnormal blood tests, problems with bleeding and bruising, increases in transaminases (a group of enzymes occurring naturally in the blood) which may be a sign of liver problems. The doctor may want to perform tests periodically to check these.
Increases and decreases in blood sugar levels have also been seen. If the patient has diabetes, careful monitoring of blood sugar levels should be continued.
There have been rare postmarketing reports of cognitive impairment (e.g., memory loss, forgetfulness, amnesia, memory impairment, confusion) associated with statin use. These cognitive issues have been reported for all statins. The reports are generally nonserious, and reversible upon statin discontinuation, with variable times to symptom onset (1 day to years) and symptom resolution (median of 3 weeks).
Increase in HbA1c and fasting serum glucose levels have been reported with HMG-CoA reductase inhibitors.
If the patient gets any of these, or any other unusual effects, the doctor or pharmacist should be told at once.
There are some medicines that may interact with DIVATOR, these are: Medicines used to modulate immune response, e.g. cyclosporin or antihistamines such as terfenadine, astemizole.
Macrolide antibiotics, e.g. erythromycin; azole antifungal medicines, e.g. ketoconazole, itraconazole; rifampicin (an antibiotic).
Medicines to regulate lipid levels, e.g. fibric acid derivatives, niacin, colestipol.
Some calcium channel blockers used for angina or high blood pressure, e.g. nifedipine; some benzodiazepines used for anxiety and other conditions, e.g. diazepam; medicines to regulate heart rhythm.
Protease inhibitors used in the treatment of HIV e.g. nelfinavir.
Digoxin, warfarin, oral contraceptives, antacids, phenytoin (an anti-convulsant for epilepsy).
Co-administration of strong CYP3A4 inhibitors (e.g. ciclosporin, telithromycin, clarithromycin, delavirdine, stiripentol, ketoconazole, voriconazole, itraconazole, posaconazole and HIV protease inhibitors including ritonavir, lopinavir, atazanavir, indinavir, darunavir, etc.) should be avoided if possible. In cases where co-administration of these medicinal products with atorvastatin cannot be avoided, lower starting and maximum doses of atorvastatin should be considered and appropriate clinical monitoring of the patient is recommended.
In patients taking telaprevir, concomitant use of atorvastatin should be avoided.
The dose of atorvastatin should not exceed 40 mg daily when taking with boceprevir and close clinical monitoring is recommended.
When taking DIVATOR, do not drink more than one or two small glasses of grapefruit juice per day.
It is important to tell the doctor about all the medicines being taken, including those that have been bought without a prescription.
Remember: This medicine is for the patient. Only the doctor can prescribe DIVATOR for the patient. Never give it to anyone else. It may harm them even if their condition is the same.
If there are any further questions about the medicine or treatment, ask the doctor or pharmacist.
Keep the tablets at normal room temperature in the packaging they come in.
C10AA05 - atorvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia.
Divator tab 10 mg
3 × 10's
Divator tab 20 mg
3 × 10's
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