As with all medicines, DIVATOR can sometimes cause side-effects in some individuals. The most commonly reported ones are: Nausea, abdominal pain, constipation, wind, indigestion, headache, muscle pain, weakness, diarrhoea and insomnia.
Other less common side-effects have been seen in some patients taking DIVATOR or other medicines of this kind. Not all of these effects have necessarily been linked to the use of these medicines. These include: Muscle cramps, weakness or tenderness, numbness or tingling in the fingers and toes, impotence, pancreatitis (inflammation of the pancreas leading to stomach pain), hepatitis (liver inflammation), jaundice (yellowing of the skin and whites of the eyes), loss of appetite, vomiting, hair loss, itching, rash (rarely severe blistering rash with associated general illness), chest pain, dizziness, allergic reactions, joint pain, loss of memory, back pain, weight gain, oedema (e.g. ankle swelling), feeling tired, noises in the ears and/or head, reduction in sensation of skin to light, touch or pain.
Angioneurotic oedema (swelling of the face, tongue and windpipe which can cause great difficulty in breathing). This is a very rare reaction which can be serious if it occurs. The patient should tell the doctor immediately if it happens.
Rarely, patients have developed muscle wasting or inflammation, and very rarely this has progressed to become a serious potentially life-threatening condition (called "rhabdomyolysis"). If having muscle weakness, tenderness or pain and particularly at the same time, feeling unwell or having a high temperature, stop taking DIVATOR and tell the doctor immediately. Consult the doctor as soon as possible if experiencing symptoms suggestive of liver complaint (see Contraindications).
Abnormal blood tests, problems with bleeding and bruising, increases in transaminases (a group of enzymes occurring naturally in the blood) which may be a sign of liver problems. The doctor may want to perform tests periodically to check these.
Increases and decreases in blood sugar levels have also been seen. If the patient has diabetes, careful monitoring of blood sugar levels should be continued.
There have been rare postmarketing reports of cognitive impairment (e.g., memory loss, forgetfulness, amnesia, memory impairment, confusion) associated with statin use. These cognitive issues have been reported for all statins. The reports are generally nonserious, and reversible upon statin discontinuation, with variable times to symptom onset (1 day to years) and symptom resolution (median of 3 weeks).
Increase in HbA1c and fasting serum glucose levels have been reported with HMG-CoA reductase inhibitors.
If the patient gets any of these, or any other unusual effects, the doctor or pharmacist should be told at once.