Tell the doctor as soon as possible if not feeling well while taking duloxetine or if there are any questions or concerns.
Do not be alarmed by the following lists of side effects. The patient may not experience any of them. All medicines can have side effects. Sometimes they are serious but most of the time they are not.
Tell the doctor or pharmacist if any of the following is noticed and worries the patient.
This list includes the more common side effects. Mostly, these are mild: dry mouth, mouth ulcers, thirst, bad taste; burping or belching, indigestion, stomach pain, nausea, vomiting; constipation, diarrhoea, wind (flatulence); bad breath; loss of appetite, weight loss; headache; trouble sleeping; dream abnormalities; drowsiness; feeling tired or having no energy; sexual problems; dizziness; tremor; blurred vision; feeling anxious, agitated or restless; confusion and attention problems; tingling and numbness of hands, face, mouth and feet; yawning or throat tightness; difficulty urinating (passing water), urinating frequently or needing to urinate at night; irregular heart beat; hot and cold sweats; sore ears, sore throat; ringing in ears; muscle pain, stiffness or twitching; walking problems; flushing; skin rash; restless legs.
Tell the doctor as soon as possible if any of the following is noticed.
These may be serious side effects. The patient may need medical attention. Most of these side effects are rare: Signs of a possible liver problem, such as itchy skin, dark urine, yellowing of the skin or eyes, tenderness over the liver, symptoms of the 'flu'.
High pressure in the eye (glaucoma).
Feeling tired, weak or confused and having aching, stiff or uncoordinated muscles. This may be because the patient has low sodium levels in the blood (hyponatraemia or syndrome of inappropriate antidiuretic hormone).
Seeing or hearing things (hallucinations).
Dizziness or fainting when standing up, especially from a lying or sitting position.
Uncontrollable movements.
If the patient has some or all of the following symptoms he/she may have something called serotonin syndrome: feeling confused, feeling restless, sweating, shaking, shivering, hallucinations, sudden jerks in the muscles or a fast heart beat.
Stiff neck or jaw muscles (lockjaw).
Fits or seizures.
Mood of excitement, over-activity and uninhibited behaviour.
Aggression or anger especially after starting or stopping taking this medicine.
Other changes the patient may not be aware of: increased blood pressure; heart rhythm changes; underactive thyroid gland; liver function changes.
Other side effects not previously listed may occur in some patients.
Allergic reactions: If the patient thinks he/she is having an allergic reaction to duloxetine, the patient must not take any more of this medicine and tell the doctor immediately or go to the Accident and Emergency department at the nearest hospital.
Symptoms of an allergic reaction may include some or all of the following: cough, shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue, or other parts of the body; rash, itching or hives on the skin; fainting; hayfever-like symptoms.