Tablet: Probenecid may increase amoxicillin levels. Increased effect of anticoagulants with amoxicillin. Efficacy of oral contraceptives may be reduced when taken with AMK.
Powder for oral suspension: Probenecid: Oral probenecid administered shortly before or concomitantly with amoxicillin and clavulanate potassium slows the rate of renal tubular secretion of amoxicillin and produces higher and prolonged serum concentrations of amoxicillin.
Allopurinol: Increased incidence of rash reportedly occurs in patients with hyperuricemia who are receiving allopurinol and concomitant amoxicillin compared with those receiving amoxicillin or allopurinol alone.
Disulfiram: There is no evidence to date that concomitant use of the drugs would result in a disulfiram-like reaction, and the need for precaution when concomitant use of the drugs is considered has been questioned.