AMK Dosage/Direction for Use

Tablet: In Children: The exact doses are based on body weight. Depending upon severity of infection, the daily dose in children under 40 kg body weight is 20-40 mg/kg body weight (based on the amoxicillin component) in divided dose three times daily.
Adults and children over 12 years: Mild-Moderate infections: AMK 375 mg tablet three times a day.
Severe infections: AMK 1 g tablet two times a day.
In patients with severe renal insufficiency (creatinine clearance 10 to 30 ml/min) the dose should be adequately adjusted or the dosing interval prolonged, in anuria to 48 hours or more (creatinine clearance less than 5 ml/min).
Powder for oral suspension: AMK 156/457 for oral suspension should be reconstituted at the time of dispensing by adding the water to the mark on the bottle. After tapping the bottle to thoroughly loosen the powder for oral suspension, the water should be added to the powder in 2 portions and the suspension agitated well after each addition. The suspension should be agitated well just prior to administration of each dose.
Usual dose range: Dosage of amoxicillin and clavulanate potassium generally is expressed in terms of the amoxicillin content of the fixed combination.
Infants <3 months: Oral: 30 mg/kg/day divided every 12 hours using 125 mg/5 ml of amoxicillin.
Children ≥3 months and <40 kg: Oral: 20-90 mg/kg/day divided every 8-12 hours.
Children ≥40 kg and Adults: Oral: 250-500 mg every 8 hours or 875 mg every 12 hours.