Đăng xuất
Pharmacological Group: Sex hormones, progesterone pregnant (4) derivatives. ATC Code: G03DA04.
Pharmacology: Pharmacodynamics: Mechanism of Action: Darstin contains pure progesterone, dispersed into an appropriate excipient for transdermal absorption. Its estrogen-blocking effect helps balance the local estrogen and progesterone levels.
The drug's mechanism of action directly affects the breast tissue, where hormone concentrations are high. Since Darstin generally does not cause side effects, it is well-tolerated.
Darstin helps prevent the impact on blood vessels and cells caused by local progesterone deficiency in breast tissue. At this concentration, progesterone is indicated to: Prevent capillary permeability increase caused by estrogen.
Counteract the development and differentiation of mammary glands and small exocrine ducts.
Block epithelial cell division caused by estrogen.
Pharmacokinetics: Absorption: The absorption rate is approximately 10% of the prescribed dose.
Metabolism: About 80% of the absorbed drug will be metabolized through the mammary glands, but only 20% will enter the systemic circulation.
