The levels/effects of lacosamide may be increased by: Antiarrhythmic agents (class III), antiepileptic agents (sodium channel blockers), bradycardia-causing agents, CYP3A4 inhibitors (strong), lidocaine (systemic), mexiletine, QT-prolonging class IA antiarrhythmics (highest risk), QT-prolonging class IC antiarrhythmics (moderate risk).
The levels/effects of lacosamide may be decreased by: Mefloquine, mianserin, orlistat.
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