Vosamide Mechanism of Action

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

The information highlighted (if any) are the most recent updates for this brand.

Full Prescribing Info

Action

Pharmacology: Pharmacodynamics: In vitro studies have shown that lacosamide stabilizes hyperexcitable neuronal membranes by enhancing the slow inactivation of sodium channels (with no effects on fast inactivation of sodium channels).
Pharmacokinetics: Absorption: Tmax, oral: 1 to 4 hours.
Bioavailability, oral: 100%.
Effects of food: None.
Distribution: Protein binding: 14%.
V_d: 0.6 L/kg.
Metabolism: Major metabolite: O-desmethyl-lacosamide (inactive).
Substrate of CYP3A4, CYP2C9, and CYP2C19.
Excretion: Fecal excretion: Less than 0.5%.
Renal excretion: 95% (40% as unchanged drug, 30% as inactive metabolite, 20% as uncharacterized metabolite).
Dialyzable: Yes (hemodialysis), 50% removed.
Elimination Half Life: Adult: 13 hours.

Vosamide Mechanism of Action

lacosamide

Manufacturer:

Unison

Distributor:

F.C.P.

Marketer:

B.Grimm Pharma