Vilerm Special Precautions

Tablet: Care should be taken to maintain adequate hydration in patients receiving high oral dose of Acyclovir. High doses, dehydration or pre-existing renal impairment increase the risk of Acyclovir-associated acute renal failure.
Acyclovir is excreted by the kidney. The possibility of renal impairment in the elderly must be considered and the dosage should be adjusted. Both the elderly patients and patients with existing renal impairment are at increased risk of developing neurological adverse effects and should be closely monitored for evidence of these adverse effects.
Patients receiving Acyclovir for the treatment of genital herpes should avoid sexual contact while visible lesions are present since there is a risk of infecting their sexual partner. The patient should always use condoms, as the disease can also be transmitted in the absence of symptoms.
Acyclovir should be used with caution in patients receiving other nephrotoxic drugs concurrently since the risk of Acyclovir-induced renal impairment and/or reversible central nervous system (CNS) symptoms is increased in these patients. Adequate hydration should be maintained in patients receiving Acyclovir.
Powder for infusion: Administration of Acyclovir by intravenous infusion should be given slowly at a constant rate over a period more than 60 minutes to avoid precipitation of Acyclovir in the kidney.
Should adjust balances of water and electrolytes in patients with dehydration before administration of this drug.
In case of treatment of genital herpes simplex infections, patients should avoid sexual contact during treatment to prevent further infections.
Use with caution in patients receiving other nephrotoxic drugs concurrently since the risk of Acyclovir - induced renal impairment is increased in these patients.
Sodium is a component of the drug. Therefore, use with caution in patients on a controlled sodium diet.
Use in Children: Tablet: Safety and effectiveness in pediatric patients younger than 2 years have not been established.