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Sulodexide is a heparin-like molecule and may therefore increase the anticoagulative effects of heparin itself and oral anticoagulants if administered simultaneously.
As sulodexide is an acid polysaccharide, if administered in extemporary association, it may react by forming complexes with the base substances. The incompatible substances commonly used for extemporary association for phleboclysis are: Vitamin K, B-complex vitamins, hydrocortisone, jaluronidase, calcium gluconate, quaternary ammonium salts, chloramphenicol, tetracyclines and streptomycin.
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