Vessel Mechanism of Action

Pharmacotherapeutic group: Antithrombotics/heparinoids.
Pharmacology: Sulodexide is a glycosaminoglycan with a strong antithrombotic effect on both arteries and veins.
Several clinical studies carried out by administering the product orally and by injection show that its antithrombotic activity is due to dose-dependent inhibition of some coagulative factors, above all activated X factor; as interference with thrombin remains at an insignificant level, the consequences of anticoagulative action are generally avoided. Antithrombotic action is also sustained by the inhibition of platelet aggregation and the activation of the circulating and parietal fibrinolytic system.
Sulodexide also brings back to normal the viscosimetric parameters that are usually altered in patients with vascular pathologies with thrombotic risk, mainly by reducing fibrinogen levels.
A normalising effect on modified lipidic levels by activation of lipoproteinlipase completes sulodexide's pharmacological profile.