Veflox Dosage/Direction for Use

Recommended Dose: 500 mg: See Table 1.

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750 mg: For empirical treatment for community-acquired pneumonia: 750 mg once daily. (See Table 2.)

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When only the serum creatinine is known, the following formula may be used to estimate creatinine clearance: see equation.

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The serum creatinine should represent a state of renal function.
Patients with impaired liver function: No adjustment of dosage is required since levofloxacin is not metabolized to any relevant extent by liver and is mainly excreted by kidneys.
Elderly patient: No adjustment of dosage is required in the elderly, other than that imposed by consideration of renal function.
Mode of Administration: Levofloxacin is administered orally without regard to meals. Patients receiving oral levofloxacin should be well hydrated and instructed to drink fluids liberally to prevent highly concentrated urine and formation of crystals in urine. Levofloxacin should be administered orally at least 2 hours before or 2 hours after antacids containing magnesium or aluminum, metal cations (e.g., iron), sucralfate, multivitamins or dietary supplements containing iron or zinc, or buffered didanosine (pediatric oral solution admixed with antacid). These drugs may interfere with oral absorption of levofloxacin, resulting in subtherapeutic systemic concentrations of the quinolone.