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Overdose: Limited overdose data. The following have occurred with therapy: edema, hypoglycemia, hepatic enzyme elevations, paresthesia, and elevations of creatine phosphokinase.
Treatment: Decontamination: Activated charcoal.
Supportive treatment: Symptomatic and supportive. Management of hypoglycemia, fluid and electrolyte status, and hypotention may be necessary.
Monitoring of patient: Obtain a baseline blood glucose level and monitor frequently; especially when coadministered with other antidiabetic agents. Monitor hepatic enzymes following a significant overdose. Monitor vital signs, blood pressure and fluid and electrolyte status as indicated. Plasma volume expansion has been reported which may exacerbate heart failure.
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