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Recommended Doses: The initiated dose for monotherapy or combination with a sulfonylurea, metformin or insulin is 15 mg or 30 mg once daily. If the response is inadequate, the dose can be increased in increments up to 45 mg once daily. In case of pioglitazone in combination with a sulfonylurea or metformin, the current sulfonylurea dose can be continued upon initiation of pioglitazone therapy. If patients report hypoglycemia, the dose of sulfonylurea should be decreased. However, hypoglycemia does not occur during combination therapy with metformin.
Use in the children: Safety and effectiveness not established in children or adolescents younger than 18 years of age.
Mode of Administration: Pioglitazone should be taken once daily without regard to meals.
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