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Warfarin: Prothrombin time or other suitable anticoagulation test should be monitored if tigecycline is administered with warfarin.
Calcineurin Inhibitors: Concomitant use of tigecycline and calcineurin inhibitors such as tacrolimus or cyclosporine may lead to an increase in serum trough concentrations of the calcineurin inhibitors. Therefore, serum concentrations of the calcineurin inhibitor should be monitored during treatment with tigecycline to avoid drug toxicity.
Oral contraceptives: Concurrent use of antibacterial drugs with oral contraceptives may render oral contraceptives less effective.
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