Tygin Caution For Usage

Drug Compatibilities: Compatibilities intravenous solution include 0.9% Sodium Chloride Injection, USP, 5% Dextrose Injection, USP, and Lactated Ringer's Injection, USP. When administered through a Y-site, tigecycline is compatible with the following drugs or diluents when used with either 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP: amikacin, dobutamine, dopamine HCl, gentamicin, haloperidol, Lactated Ringer's, lidocaine HCl, metoclopramide, morphine, norepinephrine, piperacillin/tazobactam (EDTA formulation), potassium chloride, propofol, ranitidine HCl, theophylline, and tobramycin.
Incompatibilities: The following active substances should not be administered simultaneously through the same Y-site as tigecycline: Amphotericin B, amphotericin B lipid complex, diazepam, esomeprazole and omeprazole.
This medicinal product must not be mixed with other medicinal products except those mentioned in Special precautions for disposal and other handling as follows.
Special precautions for disposal and other handling: The powder should be reconstituted with 5.3 mL of 0.9% sodium chloride solution for injection, 5% dextrose solution for injection, or Lactated Ringer's solution for injection to achieve a concentration of 10 mg/ml of tigecycline. The vial should be gently swirled until the medicinal product is dissolved. Thereafter, 5 ml of there constituted solution should be withdrawn from the vial and added to a 100 ml intravenous container for infusion or other suitable infusion container.
For a 100 mg dose, reconstitute using two vials into a 100 ml intravenous container or other suitable infusion container. Note: The vial contains a 6% overage. Thus, 5 ml of reconstituted solution is equivalent to 50 mg of the active substance. The reconstituted solution should be yellow to orange in colour; if not, the solution should be discarded. Parenteral products should be inspected visually for particulate matter and discoloration (e.g., green or black) prior to administration.
This medicinal product is for single use only; any unused medicinal product or waste material should be disposed of in accordance with local requirements.
Compatible intravenous solutions include: 0.9% sodium chloride solution for injection, 5% dextrose solution for injection, and Lactated Ringer's solution for injection.
When administered through a Y-site, compatibility of tigecycline diluted in 0.9% sodium chloride solution for injection is demonstrated with the following medicinal products or diluents: amikacin, dobutamine, dopamine HCl, gentamicin, haloperidol, Lactated Ringer's, lidocaine HCl, metoclopramide, morphine, norepinephrine, piperacillin/tazobactam (EDTA formulation), potassium chloride, propofol, ranitidine HCl, theophylline, and tobramycin.