Trulicity: Side Effects & Dosing

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Dulaglutide

Indications/Uses

Adult & ped patients ≥10 yr w/ type 2 DM to improve glycaemic control as monotherapy when diet & exercise alone do not provide adequate glycaemic control & for whom metformin use is inappropriate due to intolerance or contraindications, or as add-on therapy in combination w/ other glucose-lowering medicinal products including insulin, together w/ diet & exercise, do not provide adequate glycaemic control. Reduce risk of major adverse CV events (eg, CV death, non-fatal MI or stroke) in adults w/ type 2 DM who have multiple CV risk factors w/ or w/o established CV disease.

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Dosage/Direction for Use

SC Inj in abdomen, thigh or upper arm. Adult Monotherapy 0.75 mg once wkly. Add-on therapy 1.5 mg once wkly. Potentially vulnerable population (eg, patient ≥75 yr) Initially 0.75 mg once wkly. Paed ≥10 yr Initially 0.75 mg once wkly. May increase to max of 1.5 mg once wkly after at least 4 wk if additional glycemic control is needed.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity.

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Special Precautions

Not to be administered IV or IM. Discontinue treatment if pancreatitis is suspected & not to be restarted if pancreatitis is confirmed. Not to be used in patients w/ type 1 DM or for treatment of diabetic ketoacidosis. Not a substitute for insulin. Not recommended in patients w/ severe GI disease including severe gastroparesis. Dehydration; acute pancreatitis. Increased risk of hypoglycaemia in combination w/ sulphonylurea or insulin. Patients w/ CHF. Monitor patients w/ history of diabetic retinopathy for progression. May cause deterioration of renal function including acute renal failure in patients w/ impaired renal function. May affect ability to drive & use machines when used in combination w/ sulphonylurea or prandial insulin. Not recommended in ESRD (<15 mL/min/1.73 m²). Not recommended during pregnancy. Not to be used during lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Hypoglycaemia; nausea, diarrhoea, vomiting, abdominal pain. Decreased appetite, dyspepsia, constipation, flatulence, abdominal distension, GERD, eructation; fatigue; sinus tachycardia, 1st degree AV block.

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Drug Interactions

Delayed gastric emptying & affected absorption rate of oral medicinal products requiring rapid GI absorption. Increased exposure, C_max & median t_max w/ sitagliptin.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Trulicity detailed prescribing information

Storage

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Description

View Trulicity description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Antidiabetic Agents

ATC Classification

A10BJ05 - dulaglutide ; Belongs to the class of glucagon-like peptide-1 (GLP-1) analogues. Used in the treatment of diabetes.

Thai FDA Category

Presentation/Packing

Form

Trulicity soln for inj 0.75 mg/0.5 mL

Packing/Price

4 × 1's

Form

Trulicity soln for inj 1.5 mg/0.5 mL

Packing/Price

4 × 1's

Trulicity

dulaglutide

Manufacturer:

Eli Lilly

Distributor:

Zuellig Pharma