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Amphotericin B: amphotericin B may enhance the adverse/toxic effect of Flucytosine, possibly by increasing cellular uptake and/or by decreasing renal excretion of Flucytosine. This may be related to the adverse effects of amphotericin B on renal function. If Flucytosine is used in conjunction with amphotericin B, serum Flucytosine concentrations and blood cell counts should be carefully monitored.
Cytarabine: cytarabine (cytosine arabinoside) may diminish the therapeutic effect of Flucytosine. Concomitant use of the drugs is not recommended.
Zidovudine: zidovudine may increase the risk of hematologic toxicity, possibly by additive or synergistic bone marrow suppression.
Laboratory test interferences: Determine measurement of serum creatinine levels by Jaffe reaction, because Flucytosine does not interfere with the determination of creatinine values by this method.
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