Tokatz Dosage/Direction for Use

Posology: Adults: 2 mg once daily.
Geriatric (>65 years): Start with 1 mg once daily (see Pharmacology: Pharmacokinetics under Actions); if needed, the dose can be increased to 2 mg once daily.
Children and adolescents: Prucalopride is not recommended in children and adolescents younger than 18 years (see Pharmacology: Pharmacodynamics under Actions).
Patients with renal impairment: The dose for patients with severe renal impairment (GFR <30 mL/min/1.73 m²) is 1 mg once daily (see Contraindications and Pharmacology: Pharmacokinetics under Actions). No dose adjustment is required for patients with mild to moderate renal impairment.
Patients with hepatic impairment: No dose adjustment is required for patients with hepatic impairment. In clinical trials, a doubling of the daily dose to 4 mg did not lead to an increase in efficacy. If the intake of once daily prucalopride is not effective after 4 weeks of treatment, the patient should be re-examined and the benefit of continuing treatment reconsidered.
If treatment is continued longer than 3 months, the benefit should be reassessed at regular intervals.
Method of Administration: Prucalopride film coated tablets are for oral use and can be taken with or without food.