Ticalor Dosage/Direction for Use

Recommended Dose: In patients with Acute Coronary Syndromes, Ticagrelor treatment should be initiated with a single 180 mg loading dose (two tablets of 90 mg) and then continued at 90 mg twice daily. Treatment is recommended for at least 12 months unless discontinuation of Ticagrelor is clinically indicated.
In patients with Acute Ischemic Stroke or Transient Ischemic Attack, initiate Ticagrelor with a single 180 mg loading dose (two tablets of 90 mg) and then continue with 90 mg twice daily for 30 days.
Patients taking Ticagrelor should also take a daily low maintenance dose of acetylsalicylic acid (ASA) of 75-150 mg, unless specifically contraindicated. An initial loading dose of ASA is recommended for patients with ACS, acute ischemic stroke or TIA.
Missed Dose: A patient who misses a dose of ticagrelor should take one 90 mg tablet (their next dose) at its scheduled time.
Conversion from Clopidogrel to Ticagrelor: Physicians who desire to switch patients from clopidogrel to Ticagrelor should administer the first 90 mg dose of ticagrelor 24 hours following the last dose of clopidogrel.
Dosage in Special Populations: Pediatric patients: Safety and efficacy in children below the age of 18 have not been established.
Elderly patients: No dose adjustment is required.
Patients with renal impairment: No dose adjustment is necessary for patients with renal impairment. No information is available concerning treatment of patients on renal dialysis.
Patients with hepatic impairment: No dose adjustment is necessary for patients with mild hepatic impairment. Ticagrelor has not been studied in patients with moderate or severe hepatic impairment.
Mode of Administration: Orally administration, can be taken with or without food.
For patients who are unable to swallow the whole tablet, tablets can be crushed to a fine powder and mixed in half a glass of water and drunk immediately. The glass should be rinsed with a further half glass of water and the contents drunk. The mixture can also be administered via a nasogastric tube (CH8 or greater). It is important to flush the nasogastric tube through with water after administration of the mixture.