At higher than recommended dosages anagrelide produces a reduction in blood pressure, which may cause hypotension as well as tachycardia. A single dose of 5 mg anagrelide can reduce blood pressure usually accompanied by vertigo.
There have been a small number of reports of overdose with anagrelide. Reported symptoms include sinus tachycardia and vomiting. Symptoms improved with conservative management.
A specific antidote for anagrelide has not been identified.
In case of overdose close clinical observation of the patient is necessary. This includes monitoring of the platelet count with regard to thrombocytopenia. If required, the dose should be decreased or administration discontinued until the platelet count returns to the normal range.
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