Thromboreductin Adverse Reactions

The following undesirable effects are ranked according to system organ class and to their frequency: Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1,000 to <1/100), Rare (≥1/10,000 to <1/1,000), Very rare (<1/10,000), Not known (cannot be estimated from the available data).
Blood and the lymphatic system disorders: Common: anaemia.
Uncommon: pancytopenia, thrombocytopenia, haemorrhage, ecchymosis.
Metabolism and nutrition disorders: Common: fluid retention.
Uncommon: oedema, weight loss.
Rare: weight gain.
Nervous system disorders: Very common: headaches.
Common: dizziness.
Uncommon: depression, amnesia, confusion, insomnia, paraesthesia, hypoaesthesia, nervousness, dry mouth.
Unknown: cerebral infarction*.
Eye disorders: Rare: diplopia, vision abnormal.
Ear and labyrinth disorders: Rare: tinnitus.
Cardiac disorders: Common: tachycardia, palpitations.
Uncommon: ventricular tachycardia, congestive heart failure, atrial fibrillation, supraventricular tachycardia, arrhythmia, hypertension, syncope.
Rare: myocardial infarction, cardiomyopathy, cardiomegaly, pericardial effusion, angina pectoris, postural hypotension, vasodilatation, Prinzmetal angina.
Not known: Torsade de pointes.
Respiratory, thoracic and mediastinal disorders: Uncommon: pulmonary hypertension, pneumonia, pleural effusion, dyspnoea, epistaxis.
Rare: pulmonary infiltrates.
Not known: interstitial lung disease including pneumonitis and allergic alveolitis.
Gastrointestinal disorders: Common: diarrhoea, vomiting, abdominal pain, nausea, flatulence.
Uncommon: gastrointestinal haemorrhage, pancreatitis, anorexia, dyspepsia, constipation, gastrointestinal disorder.
Rare: colitis, gastritis, gingival bleeding.
Hepatobiliary disorders: Uncommon: hepatic enzymes increased.
Not known: hepatitis.
Skin and subcutaneous tissue disorders: Common: rash.
Uncommon: alopecia, pruritus, skin discoloration.
Rare: dry skin.
Musculoskeletal, connective tissue and bone disorders: Uncommon: arthralgia, myalgia, back pain.
Renal and urinary disorders: Uncommon: impotence.
Rare: renal failure, nocturia.
Not known: tubulointerstitial nephritis.
General disorders and administration site conditions: Common: fatigue.
Uncommon: chest pain, fever, chills, malaise, weakness.
Rare: flu-like syndrome, pain, asthenia.
Investigations: Rare: blood creatinine increased.
*Cerebral infarction - see Treatment discontinuation and thrombotic risk under Precautions.