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Before initiating therapy with Tazocin, careful inquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins and other allergens. Serious and occasionally fatal hypersensitivity [anaphylactic/anaphylactoid (including shock)] reactions have been reported in patients receiving therapy with penicillins, including piperacillin/tazobactam. These reactions are more likely to occur in persons with a history of sensitivity to multiple allergens. Serious hypersensitivity reactions require the discontinuation of the antibiotic, and may require administration of adrenaline and other emergency measures.
There have been reports of patients with a history of penicillin hypersensitivity who have experienced severe reactions when treated with a cephalosporin.
Antibiotic-induced pseudomembranous colitis may be manifested by severe, persistent diarrhea which may be life-threatening. The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment.
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