Tazocin Dosage/Direction for Use

Neutropenic patients with signs of infection (eg, fever) should receive immediate empirical antibiotic therapy before laboratory results are available.
Adults and Children Receiving the Adult Dose: The usual dosage for adults and children receiving the adult dose with normal renal function is 4.5 g Tazocin (piperacillin 4 g and tazobactam 0.5 g) given every 8 hrs.
The total daily dose depends on the severity and localization of the infection and can vary from 2.25-4.5 g Tazocin (piperacillin 2-4 g and tazobactam 0.25-0.5 g) administered every 6 or 8 hrs.
Elderly: Tazocin may be used at the same dose levels as adults except in cases of renal impairment (see as follows).
Neutropenia: Recommended Dose: 4.5 g Tazocin (piperacillin 4 g and tazobactam 0.5 g) given every 6 hrs in combination with an aminoglycoside.
Pediatric Neutropenia: For children with normal renal function, the dose should be adjusted to 90 mg/kg (piperacillin 80 mg/tazobactam 10 mg) administered every 6 hrs in combination with an aminoglycoside, not exceeding 4.5 g Tazocin (piperacillin 4 g and tazobactam 0.5 g) given every 6 hrs.
Intra-Abdominal Infections: Hospitalized Children 2-12 years with Normal Renal Function: Weighing up to 40 kg: Recommended Dose: 112.5 mg/kg (piperacillin 100 g/tazobactam 12.5 g) every 8 hrs; >40 kg: Follow the adult dose guidance ie, 4.5 g (piperacillin 4 g/tazobactam 0.5 g) every 8 hrs.
The duration of therapy should be guided by the severity of the infection and the patient's clinical and bacteriological progress. Therapy is recommended to be a minimum of 5 days and a maximum of 14 days, considering that dose administration should continue at least 48 hrs after the resolution of clinical signs and symptoms.
Renal Insufficiency: Adults and Children Receiving the Adult Dose: In adults and children receiving the adult dose with renal insufficiency and haemodialysis patients, the IV dosages and administration intervals should be adjusted to the degree of actual renal function impairment. The suggested daily doses are as follows: (See Table 1.)

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For patients on haemodialysis, the maximum daily dose is 8 g/1 g Tazocin. In addition, because haemodialysis removes 30-50% of piperacillin in 4 hrs, 1 additional dose of 2 g/250 mg Tazocin should be administered following each dialysis period. For patients with renal failure and hepatic insufficiency, measurement of serum levels of Tazocin will provide additional guidance for adjusting dosage.
Children with Renal Insufficiency <40 kg: IV dosage should be adjusted to the degree of actual renal impairment.
Children with Renal Insufficiency 2-12 years: The pharmacokinetics of piperacillin/tazobactam have not been studied in pediatric patients with renal impairment. The following dosage adjustment for pediatric patients with renal impairment 2-12 years is recommended (see Table 2).

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This dosage modification is only an approximation. Each patient must be monitored closely for signs of drug toxicity. Drug dose and interval should be adjusted accordingly.
Children <50 kg on Hemodialysis: Recommended Dose: 45 mg/kg every 8 hrs.
Duration of Therapy: In acute infections, treatment with Tazocin should be continued for 48 hrs beyond the resolution of clinical symptoms or fever.
Administration: Tazocin may be given by slow IV injection (over at least 3-5 min) or by slow IV infusion (over 20-30 min).
Reconstitution Directions: IV Injection: Each vial of Tazocin 4.5 g should be reconstituted with 20 mL of one of the following diluents:
Diluents for Reconstitution: 0.9% Sodium Chloride for Injection; Sterile Water for Injection; Dextrose 5%; Bacteriostatic Saline/Parabens; Bacteriostatic Water/Parabens; Bacteriostatic Saline/Benzyl Alcohol; Bacteriostatic Water/Benzyl Alcohol; Lactated Ringer's Solution..
Shake until dissolved. IV injection should be given over 3-5 min.
IV Infusion: Each vial of Tazocin 4.5 g should be reconstituted with at least 20 mL of one of the reconstitution diluents.
The reconstituted solution may be further diluted to the desired volume (eg, 50-150 mL) with one of the compatible solvents for IV use as follows: 0.9% Sodium Chloride for Injection; Sterile Water for Injection⁺; Dextrose 5%; and Dextran 6% in Saline.
⁺Maximum recommended volume of Sterile Water for Injection per dose is 50 mL.
Co-Administration of Piperacillin/Tazobactam with Aminoglycosides: Due to in vitro inactivation of the aminoglycosides by β-lactam antibiotics, piperacillin/tazobactam and the aminoglycoside are recommended for separate administration. Piperacillin/tazobactam and the aminoglycoside should be reconstituted and diluted separately when concomitant therapy with aminoglycosides is indicated (see Cautions for Usage).
In circumstances where co-administration is preferred, the reformulated piperacillin/tazobactam-containing EDTA supplied in vials is compatible for simultaneous co-administration via y-site infusion only with the following aminoglycosides under the following conditions. (See Table 3.)

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Compatibility of piperacillin/tazobactam with other aminoglycosides has not been established. Only the concentration and diluents for amikacin and gentamicin with the dosages of piperacillin/tazobactam listed in Table 3 have been established as compatible for co-administration via y-site infusion.
Simultaneous co-administration via y-site in any manner other than previously mentioned, may result in inactivation of the aminoglycoside by piperacillin/tazobactam.