Glibenclamide must not be used for: Patients with insulin-dependent (type 1) diabetes mellitus; Treatment of diabetic ketoacidosis; Treatment of diabetic precoma or coma; Patients with serious renal dysfunction; Patients with serious hepatic or adrenocortical dysfunction; Patients hypersensitive to Glibenclamide, other sulfonylureas, any sulfonamide derivative, or any other ingredient of the product; Pregnant women; Breast-feeding women; Patients treated with bosentan.