Sterile Ampicillin Sodium T P Dosage/Direction for Use

Posology: Usual adult dosage (including elderly patients): Septicaemia, endocarditis, osteomyelitis: 500 mg four to six times a day IM or IV for one to six weeks.
Peritonitis, intra-abdominal sepsis: 500 mg four times a day IM or IV.
Meningitis: Adult dosage: 2 g six-hourly IV.
Children dosage: 150 mg/kg daily IV in divided doses.
Ampicillin may also be administered by other routes of conjunction with systemic therapy.
Local use in abdominal surgery: 1 g sterile powder sprinkled into the wound extraperitoneally or into muscle layers to prevent wound infection post operatively.
Paediatric population: Half adult routine dosage for children under 10 years.
All recommended dosages are a guide only. In severe infections the previously mentioned dosages may be increased.
Renal Impairment: In the presence of severe renal impairment (creatinine clearance <10 ml/min) a reduction in dose or extension of dose interval should be considered. In cases of dialysis, an additional dose should be administered after the procedure.
Ampicillin sodium may be administered by IM or slow IV injection or IV infusion. For IV injection, it should be used only in the treatment of moderately severe or severe infections. Direct IV injections should be made slowly over 10-15 minutes to avoid the possibility of convulsive seizures. For intermittent IV infusion, the concentration of ampicillin and rate of infusion should be adjusted so that the total dose of the drug is administered before 10% or more of the drug is inactivated in IV solution.
The usual adult dosage for the treatment of respiratory tract or skin and skin structure infections is 250-500 mg every 6 hours.
For the treatment of GI or urinary tract infections, the usual adult dosage is 500 mg every 6 hours. For severe infections, larger doses may be required.
For the treatment of septicemia or bacterial meningitis is 8-14 g or 150-200 mg/kg daily given parenterally in equal divided doses every 3-4 hours.
For the initial treatment of septicemia or meningitis, ampicillin should be given IV for at least 3 days and continuing with IM.
Pediatric Dosage: For the treatment of respiratory tract or skin and skin structure infections, the usual dosage of ampicillin for children weighing 40 kg or less is 25-50 mg/kg daily, administered in equally divided doses every 6 hours. For the treatment of GI or urinary tract infections, the usual dosage for children weighing 40 kg or less is 50-100 mg/kg daily given in equally divided doses every 6 hours, septicemia or CNS infections the usual dosage is 100-200 mg/kg daily given in divided doses every 3-4 hours, starting with IV for 3 days and continuing with IM.
Sterile Ampicillin sodium 250 mg, 500 mg, should be reconstituted with 3 mL distilled water before injection, and 6 mL for 1 g vial.
500 mg: 1-14 g a day. It depends on body weight and severity of infection.
Adults: By injection 500 mg-1 gram a day.
Children: By injection 12.5-50 mg per kg body weight a day.
Method of administration: Intramuscular: Add 1.5 ml water for injections to 250 mg vial contents.
Add 3 ml water for injections to 500 mg vial contents.
Add 6 ml water for injections to 1,000 mg vial contents.
Intravenous: Dissolve 500 mg in 5 ml water for injections.
Administer by slow injection (three to four minutes). Ampicillin may also be added to infusion fluids or injected, suitably diluted, into the drip tube over a period of three to four minutes.
Direction for Reconstitution: 500 mg: For I.M. use: Add 1.5 mL of sterile water and shake well. The solution must be used within one hour after reconstitution.
For I.V. use: Add 5 mL of sterile water and shake well. The solutions must be used within one hour after reconstitution.