SMOFlipid 20% Dosage/Direction for Use

The patient's ability to eliminate the fat infused, should govern the dosage and infusion rate (see Precautions).
Adult: The standard dose is 1.0 - 2.0 g fat/kg body weight (b.w.)/day, corresponding to 5-10 ml/kg b.w./day. The recommended infusion rate is 0.125 g fat/kg b.w./hour, corresponding to 0.63 ml SMOFlipid/kg b.w./hour, and should not exceed 0.15 g fat/kg b.w./hour, corresponding to 0.75 ml SMOFlipid/kg b.w./hour.
Neonates and infants: The initial dose should be 0.5 - 1.0 g fat/kg b.w./day followed by a successive increase by 0.5 - 1.0 g fat/kg b.w./day up to 3.0 g fat/kg b.w./day.
It is recommended not to exceed a daily dose of 3 g fat/kg b.w./d, corresponding to 15 ml Smoflipid/kg b.w./day.
The rate of infusion should not exceed 0.125 g fat/kg b.w./hour.
In premature and low birthweight neonates, Smoflipid should be infused continuously over about 24 hours.
Children: It is recommended not to exceed a daily dose of 3 g fat/kg b.w./d, corresponding to 15 ml Smoflipid/kg b.w./ day.
The daily dose should be increased gradually during the first week of administration.
The infusion rate should not exceed 0.15 g fat/kg b.w./hour.
Administration: Intravenous infusion into a peripheral or central vein.