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Hypersensitivity to bosentan or any component of the formulation; concurrent use of cyclosporine or glyburide; use in women who are or may become pregnant.
Canadian labeling: Additional contraindications (not in U.S. labeling): Moderate to severe hepatic impairment and/or baseline ALT or AST >3 times the upper limit of normal (ULN), particularly when total bilirubin >2 times ULN.
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