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Central nervous system: Headache.
Endocrine & metabolic: Fluid retention.
Hematologic & oncologic: Anemia, decreased hemoglobin (typically in first 6 weeks of therapy).
Hepatic: Increased serum ALT (dose-related), increased serum AST (dose-related).
Neuromuscular & skeletal: Arthralgia.
Respiratory: Respiratory tract infection, sinusitis.
Rare but important or life-threatening: Anaphylaxis, DRESS syndrome, fluid retention, hepatic cirrhosis (prolonged therapy), hepatic failure (rare), hypersensitivity reaction, leukopenia, neutropenia, severe anemia, skin rash, thrombocytopenia.
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