Silatio Drug Interactions

Avoid concomitant use of Sildenafil with any of the following: Alprostadil, Amyl nitrate; Boceprevir; Conivaptan; Dapoxetine; Fusidic acid (Systemic); Idelalisib; Molsidomine; Phosphodiesterase 5 Inhibitors; Riociguat; Telaprevir; Vasodilators (organic nitrates).
Sildenafil may increase the levels/effects of Alpha1-Blockers, Alprostadil, Amyl Nitrile; Blood Pressure Lowering Agents; Bosentan; Phosphodiesterase-5 inhibitors, Riociguat, Vasodilators (organic nitrates).
The levels/effects of Sildenafil may be increased by: Alcohol (Ethyl); Aprepitant; Boceprevir; Clarithromycin; Conivaptan; CYP3A4 Inhibitors (Moderate); CYP3A4 Inhibitors (Strong); Dapoxetine; Dasatinib; Erythromycin (Systemic); Fluconazole; Fosaprepitant; Fusidic acid (Systemic); Idelalisib; Itraconazole; Ivacaftor; Ketoconazole (Systemic); Lorcaserin; Mifepristone; Molsidomine; Nefazodone; Netupitant; Palbociclib; Posaconazole; Protease Inhibitors; Sapropterin; Saquinavir; Simeprevir; Stiripentol; Telaprevir; Telithromycin; Voriconazole.
The levels/effects of Sildenafil may be decreased by: Bosentan; CYP3A4 Inducers (Moderate); CYP3A4 Inducers (Strong); Dabrafenib; Deferasirox; Enzalutamide; Etravirine; Mitotane; Siltuximab; St. John's Wort, Tocilizumab.
Grapefruit juice may increase serum levels/toxicity of sildenafil; avoid grapefruit juice.