Siagran Dosage/Direction for Use

The tablets should be swallowed whole with water. Administer as soon as symptoms appear.
Adults: Maximum oral dose of Sumatriptan is 300 mg daily.
Single oral Sumatriptan doses of 50 or 100 mg are recommended for management of acute migraine pain. If the headache returns or the patient has a partial response to the initial dose, the dose may be repeated after 2 hours, a second oral dose of up to 100 mg may be given.
If the first attack of migraine treated with Sumatriptan fails to respond to the drug, the diagnosis of migraine should be reconsidered before Sumatriptan is administered to treat subsequent attacks.
Children and Adolescents (under 18 years of age): There are insufficient data to make a recommendation for the use of Sumatriptan in this population.
Elderly (over 65 years of age): Use is not recommended because of the risk of adverse reactions in elderly patients who have reduced renal function, hepatic function and/or cardiac function and of concomitant disease. Moreover, the experience of the use of Sumatriptan in patients aged over 65 years is limited.
Hepatic impairment: Oral Sumatriptan therapy is considered in patients with mild to moderate hepatic impairment. The maximum single dose generally should not exceed 50 mg because the bioavailability of Sumatriptan following oral administration may be increased markedly in patients with liver disease. Severe hepatic impairment is contraindication.
Renal impairment: It has not been evaluated in renal impairment patient so there are no dosage adjustments. However, dosage adjustment not expected due to extensive metabolism to inactive agents.