Samnir Special Precautions

Prior to initiation of Cefdinir therapy, careful inquiry should be made concerning previous hypersensitivity reactions to other cephalosporins including penicillins. Because there is evidence of cross-allergenicity among cephalosporins and other β-lactam antibiotics, including penicillins. Cefdinir should be used with caution in patients with a history of hypersensitivity to penicillins, other cephalosporins and patients with a personal or familial predisposition to allergic reactions such as asthma, rash or urticaria.
Cefdinir is broad-spectrum antibiotic, prolonged treatment may result in the possible overgrowth of resistant organisms. If superinfection occurs during therapy, appropriate alternative therapy should be administered.
Dose adjustment is needed. Use with caution in patients with impaired renal function.
As with all broad-spectrum antibiotics, Cefdinir should be used with caution in individuals with a history of gastrointestinal disease, particularly colitis.
Mild cases of pseudomembranous colitis usually respond to drug discontinuation alone. In severe cases, consideration should be given to management with fluids, electrolytes, protein supplementation and treatment with an antibacterial drug clinically effective against Clostridium difficile.
Use in Children: Safety and efficacy of Cefdinir in neonates and infants younger than 6 months of age have not been established, then Cefdinir should not be used in neonates and infants younger than 6 months of age.