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Head and Neck Cancer: Recommended Initial Dose: 5 mg 3 times daily. Dosage should be titrated according to therapeutic response and tolerability. Usual Dosage Range: 3-6 tabs or 15-30 mg/day [not to exceed 2 tabs (10 mg)/dose]. Although early improvement may be realized, at least 12 weeks of uninterrupted therapy with Salagen may be necessary to assess whether a beneficial response will be achieved. The incidence of the most common adverse events increases with dose. The lowest dose that is tolerated and effective should be used for maintenance.
Sjogren's Syndrome: Recommended Dose: 5 mg 4 times daily.
Efficacy was established by 6 weeks of use.
Hepatic Impairment: Moderate: Initial Dose: 5 mg twice daily, followed by adjustment based on therapeutic response and tolerability.
Mild: No dosage reduction is required.
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