Ryaltris Dosage/Direction for Use

Dosage: Adults and Adolescents (12 Years of Age and Older): The recommended dosage of RYALTRIS is 2 sprays in each nostril twice daily.
Children (6 to 11 Years of Age): The recommended dosage of RYALTRIS is 1 spray in each nostril twice daily.
Method of administration: Administer RYALTRIS by the intranasal route only. Shake the bottle well before each use.
Priming: Prime RYALTRIS before initial use by releasing 6 sprays. One bottle of RYALTRIS provides either 240, 120 or 56 metered sprays after priming, depending on the bottle presentation. When RYALTRIS has not been used for ≥14 days, re-prime by releasing 2 sprays or until a fine mist appears.
Depending on the presentation, the bottle should be discarded after 240 sprays (30 days usage for adults and adolescents 12 years and older OR 60 days usage for children 6 to 11 years old), 120 sprays (15 days usage for adults and adolescents 12 years and older OR 30 days usage for children 6 to 11 years old) or 56 sprays (7 days usage for adults and adolescents 12 years and older OR 14 days usage for children 6 to 11 years old). The correct amount of remaining medication in each spray cannot be assured beyond the initial priming and 240, 120 or 56 sprays (depending on the bottle presentation), even though the bottle appears not being completely empty.
Avoid spraying RYALTRIS into the eyes or mouth.
Paediatric: In children 6 to 11 years of age, safety of RYALTRIS beyond 2 weeks of use has not been assessed (see Precautions).
The safety and effectiveness of RYALTRIS in paediatric patients below the age of 6 years has not been established.
Hepatic impairment: See Precautions.