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Discontinue if angioedema occurs. Patients with biliary obstructive disorders. Correct sodium &/or volume depletion prior to starting treatment. Monitor BUN & serum creatinine in patients with bilateral or unilateral renal artery stenosis. Perform assessment of renal function in patients with heart failure or post-myocardial infarction. Concomitant use with ACE inhibitors & β-blocker in patients with heart failure; drugs blocking renin-angiotensin system eg, ACE inhibitors or aliskiren. Avoid concomitant use with aliskiren in patients with severe renal impairment (GFR <30 mL/min).
Use in Pregnancy & Lactation: See Use in Pregnancy & Lactation section for further information.
Use with caution in women of childbearing potential.
Use in Children: Use with caution in children & adolescents <18 yr.
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