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Hypertension: 80 mg or 160 mg once daily. May be increased to 320 mg, or add a diuretic if blood pressure is inadequately controlled.
Heart failure: 40 mg twice daily. May be up-titrated to 80 mg & 160 mg twice daily as tolerated. Max daily dose: 320 mg in divided doses.
Post-myocardial infarction: Initially 20 mg twice daily as early as 12 hours after myocardial infarction. Titrate to 40 mg, 80 mg, & 160 mg twice daily over next few weeks, or until a dose level of 80 mg twice daily 2 weeks after treatment initiation is achieved. Target max dose in 3 months: 160 mg twice daily.
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