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Pregnancy: Data lacking on use of sitagliptin in pregnant women. In animal studies, no adverse developmental effects observed when sitagliptin was administered to pregnant rats and rabbits during organogenesis at doses ≤30 times the human 100-mg dose (based on AUC).
Lactation: Sitagliptin distributed into milk in rats; not known whether distributed into human milk. Use caution.
Fertility: Animal data do not suggest an effect of treatment with sitagliptin on male and female fertility. Human data are lacking.
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