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Drugs Metabolized by Hepatic Microsomal Enzymes: Does not inhibit CYP isoenzymes 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, or 3A4 in vitro or induce CYP3A4. Pharmacokinetic interactions with drugs metabolized by these isoenzymes unlikely.
Drugs Affecting or Affected by P-glycoprotein (P-gp) Transport System: Substrate of P-gp transport system. Potential pharmacokinetic interaction (increased absorption and renal clearance of sitagliptin) with P-gp inhibitors.
Clinically important pharmacokinetic interactions with P-gp inhibitors unlikely. Does not appear to inhibit P-gp transport system. Pharmacokinetic interactions with substrates of P-gp unlikely.
Drugs Secreted by Renal Tubular Cationic Transport: Substrate of organic anion transport system; pharmacokinetic interaction unlikely with substrates of organic cationic transport system.
Protein-bound Drugs: Pharmacokinetic interaction unlikely.
Specific Drugs: See table.
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