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Oral: Adults: Parkinson disease: Monotherapy or adjunctive therapy (not including levodopa): 1 mg once daily (maximum: 1 mg once daily).
Adjunctive therapy with levodopa: Initial: 0.5 mg once daily; may increase to 1 mg once dailY based on response and tolerability (maximum: 1 mg once daily).
Dose reduction with concomitant ciprofloxacin or other CYP1A2 inhibitors: Maximum dose: 0.5 mg once daily.
Dosage adjustment in renal impairment: Mild to moderate impairment: No dosage adjustment necessary.
Severe impairment: There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).
Dosage adjustment in hepatic impairment: Mild impairment (Child-Pugh score 5 to 6): Maximum dose: 0.5 mg once daily.
Moderate to severe impairment (Child-Pugh score 7 to 15): Use is not recommended.
Dietary Considerations: Avoid products containing high amount of tyramine (> 150 mg), such as aged cheeses (eg, Stilton cheese).
Administration: Administer without regard to meals.
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