Rasalect 1: Side Effects & Dosing

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Rasagiline

Indications/Uses

Parkinson's disease as monotherapy or adjunct therapy.

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Dosage/Direction for Use

Monotherapy or adjunct therapy 1 mg once daily. Max: 1 mg/day. In combination w/ levodopa, w/ or w/o other Parkinson disease agents Initially 0.5 mg once daily, may be increased to 1 mg once daily. Max: 1 mg/day.

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Administration

May be taken with or without food: Avoid products containing high amounts of tyramine (>150 mg), such as cheese, meats (eg, sausage or salami), bean pods, beers & soybean.

Contraindications

Concomitant use w/ MAOIs (including other specific MAO-B inhibitors), meperidine, methadone, propoxyphene or tramadol, St. John's wort, dextromethorphan

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Special Precautions

Closely monitor patients w/ HTN & orthostatic hypotension; melanoma. Patients w/ mild hepatic impairment. Do not use in patients w/ moderate-severe hepatic impairment. Drowsiness. Serotonin syndrome & dyskinesia may occur w/ antidepressant & levodopa, respectively.

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Use In Pregnancy & Lactation

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Adverse Reactions

Headache, dyskinesia (w/ levodopa), rash, wt loss, depression, serotonin syndrome.

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Drug Interactions

Increased risk of serotonin syndrome w/ MAOIs (including other specific MAO-B inhibitors), eg, meperidine, methadone, propoxyphene or tramadol & other specific MAO-B inhibitors. Increased conc w/ CYP1A2 inhibitors & peginterferon α-2b. Increased risk of side effects eg, HTN & hypertensive crisis w/ food rich in tyramine.

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Description

View Rasalect 1 description for details of the chemical structure and excipients (inactive components).

Action

View Rasalect 1 mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Antiparkinsonian Drugs

ATC Classification

N04BD02 - rasagiline ; Belongs to the class of dopaminergic agents, monoamine oxidase B inhibitors. Used in the management of Parkinson's disease.

Thai FDA Category

Presentation/Packing

Form

Rasalect 1 tab 1 mg

Packing/Price

4 × 7's

Rasalect 1

rasagiline

Manufacturer:

Unison

Distributor:

Medline

Marketer:

B.Grimm Pharma