Quetaz Drug Interactions

Given the primary central nervous system effects of quetiapine, quetiapine should be used with caution in combination with other centrally acting medicinal products and alcohol.
Caution should be exercised treating patients receiving other medications having anticholinergic (muscarinic) effects.
Cytochrome P450 (CYP) 3A4 is the enzyme that is primarily responsible for the CYP450 mediated metabolism of quetiapine. Concomitant administration of quetiapine with potent inhibitors of CYP3A4 such as erythromycin, fluconazole, itraconazole, and ketoconazole is not recommended, causes an increasing in the AUC of quetiapine. Concomitant administration of quetiapine with potent inducers of CYP3A4 such as carbamazepine, and phenytoin is significantly increased the clearance of quetiapine. As a consequence of this interaction, lower plasma concentrations can occur, which could affect the efficacy of quetiapine therapy.
Antipsychotic: Caution should be exercised when quetiapine is used concomitantly with medicinal products such as risperidone known to cause electrolyte imbalance or to increase QT interval.