Each ml contains Povidone-Iodine 70 mg equivalent to Iodine 7 mg.
Pharmacology: Pharmacodynamics: Povidone-Iodine is an iodophore that is used as a disinfectant and antiseptic. Iodophores are loose complexes of Iodine and carrier polymers. Solutions of Povidone-Iodine gradually release Iodine to exert an effect against bacteria, fungi, viruses, protozoa, cysts, and spores; the efficacy of killing pathogens depend on the concentration and duration of exposure to the drug. Povidone-Iodine is thus less potent than preparations containing free iodine but it is less toxic.
Pharmacokinetics: The extent of systemic absorption of Povidone-Iodine depends on the localization and the conditions of its use (area, mucous membranes, wounds). Iodine cross the placenta and are distributed into breast milk.
Use as a gargle to kill bacteria in the mouth and upper throat and thus help relieve inflammation caused by infection of the mouth and throat.
Recommended Dose: Gargle with 30 ml of Puvadon 30-fold dilution (in proportion of 1 ml of medicine to about 30 ml of water) for up to 30 seconds without swallowing. Repeat up to four times daily.
Mode of Administration: Use as a gargle.
Over exposure may cause local irritation to the mucous membrane. It can be absorbed through broken skin or lungs. High concentration in blood may cause thyroid disorder, renal disturbances, acidosis and electrolyte disturbances. Emergency first aid: eye- immediately wash with running water for 5 minutes. Get medical attention if irritation persists. Skin- avoid prolonged contact with excess wet solution. If irritation develops, get medical attention. Ingestion- if swallowed, do not induce vomiting. Drink several glasses of water or milk. Obtain immediate medical attention. Inhale- if fumes cause respiratory discomfort moves to fresh air.
Hypersensitivity to iodine, thyroid diseases, renal failure, pregnancy, nursing, and neonates younger than 6 months.
Povidone-Iodine can cause hypersensitivity reactions and irritation of the mucous membranes, although severe reactions are rare and Povidone-Iodine is considered to be less irritant than iodine. The excessive iodine absorption or prolonged use may produce the systemic adverse effects such as metabolic acidosis, hypernatremia, and renal impairment. Hyperthyroidism or hypothyroidism may occur after ingestion or absorption of large quantities. Hypothyroidism has occurred in neonates both as a result of absorption of Iodine from Povidone-Iodine applied to the neonate and also to the mother during pregnancy or breast feeding. Povidone-Iodine application is contra-indicated in premature neonates or those weighing less than 1.5 kg.
Regular or prolonged use should be avoided in patients with thyroid disorders or those receiving lithium therapy.
Iodine cross the placenta and are distributed into breast milk. It is better to avoid the use of iodine-containing antiseptics in pregnancy and neonates. Hypothyroidism has occurred in neonates both as a result of absorption of iodine from Povidone-Iodine applied to the neonate and also to the mother during pregnancy or breast feeding.
Povidone-Iodine can cause hypersensitivity reactions and irritation of the mucous membranes, although severe reactions are rare and povidone-iodine is considered to be less irritant than iodine.
The excessive iodine absorption or prolonged use may produce the systemic adverse effects such as metabolic acidosis, hypernatremia, and renal impairment. Hyperthyroidism or hypothyroidism may occur after ingestion or absorption of large quantities.
Lithium can potentiate the antithyroid action of Iodide. Regular or prolonged use should be avoided in patients with thyroid disorders or those receiving lithium therapy.
Store below 30°C and protect from light.
R02AA15 - povidone-iodine ; Belongs to the class of antiseptics used in throat preparations.
Puvadon gargle 70 mg/mL
30 mL x 1's
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