Pradox Drug Interactions

Metabolism/Transport Effects Inhibits: CYP2C19 (weak); Induces CYP3A4 (weak).
Avoid Concomitant Use: There are no known interac­tions where it is recommended to avoid concomitant use.
Increased Effect/Toxicity: Topiramate may increase the levels/effects of: Alcohol (Ethyl); cns depressants; divalproex; lithium; methotri­meprazine; phenytoin; valproic Acid.
The levels/effects of Topiramate may be increased by: Droperidol; methotrimeprazine; thiazide diuretics.
Decreased Effect: Topiramate may decrease the levels/effects of: Contra­ceptives (estrogens); contraceptives (progestins); sax­agliptin.
The levels/effects of Topiramate may be decreased by: Carbamazepine; ketorolac; ketorolac (systemic); meflo­quine; phenytoin.
Ethanol/Nutrition/Herb Interactions: Ethanol: Avoid ethanol (may increase CNS depression).
Food: Ketogenic diet may increase the possibility of acido­sis and/or kidney stones.
Herb/Nutraceutical: Avoid evening primrose (seizure threshold decreased).