Pradox | Mechanism of Action

Concise Prescribing Info Full Prescribing Info Contents Action Indications/Uses Dosage/Direction for Use Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Full Prescribing Info

Action

Pharmacotherapeutic Group: Anticonvulsant.
Pharmacology: Pharmacodynamics: Mechanism of Action: Anticonvulsant activity may be die to a combination of potential mechanisms: Blocks neuronal voltage-dependent sodium channels, enhances GABA (A) activity, antagonizes AMPA/kainate glutamate receptors, and weakly inhibit carbonic anhydrase.
Pharmacokinetics: Absorption: Good, rapid; unaffected by food.
Protein binding: 15% to 41% (inversely related to plasma concentrations).
Metabolism: Hepatic via P450 enzymes.
Bioavailability: ~80%.
Half-Life Elimination: Mean: Adults: Normal renal function: 21 hours; shorter in pediatric patients.
Elderly: ~24 hours.
Excretion: Urine (~70% to 80% as unchanged drug).
Dialyzable: Significantly hemodialyzed; dialysis clearance: 120 mL/minute (4-6 times higher than in adults with normal renal function); supplemental doses may be required.

Pradox Mechanism of Action

topiramate

Manufacturer:

Unison

Distributor:

Medline

Marketer:

B.Grimm Pharma