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Prucalopride is film coated tablet for oral administration without regard to meals.
Adult: 2 mg once daily.
Geriatric (age >65 years): Initial dose 1 mg once daily may increase to 2 mg once daily if necessary.
Children & adolescent: Prucalopride should not be used in children and adolescents younger than 18 years.
Dose adjustment: Renal impairment: The dose for patients with severe renal impairment (GFR <30 mL/min/1.73 m2) is 1 mg once daily and no dose adjustment for patients with mild to moderate renal impairment.
Hepatic impairment: No dose adjustment for patients with mild to moderate hepatic impairment (Child Pugh class A or B) and patients with severe hepatic impairment (Child Pugh class C) is 1 mg once daily may increase to 2 mg once daily if needed and well tolerated.
If the intake of once daily prucalopride in not effective after 4 weeks of treatment the patient should be re-examined and the benefit of continue treatment reconsidered.
Reassess for therapeutic benefit at regular intervals if prolong therapy (>3 months) is needed.
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