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Pharmacology: Pharmacodynamics: Prucalopride is a selective agonist of serotonin type 4 (5-HT4) receptors resulting in gastrointestinal prokinetic stimulation that increases colonic motility as measured by the number of high-amplitude propagating contractions (HAPCs).
Pharmacokinetics: Absorption: Rapid.
Distribution: Vd: 567 L.
Protein binding: ~30%.
Metabolism: Substrate of CYP3A4 (in vitro), not extensively metabolized.
Bioavailability: > 90%, Concomitant intake of food does not influence the oral bioavailability.
Half-life elimination: ~24 hours.
Time to peak: 2-3 hours.
Excretion: Primarily as unchanged drug: Urine (55.1%-73.8%), feces (3.7%-8.1%).
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