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Reproduction studies in mice and rats using various combinations of Piperacillin and Tazobactam have not revealed evidence of harm to the fetus. In addition, studies in mice and rats using Piperacillin alone or Tazobactam alone have not revealed evidence of harm to the fetus.
Piperacillin and Tazobactam both cross the placenta. There are no adequate or controlled studies using Piperacillin or Tazobactam alone or Piperacillin and Tazobactam in pregnant women so the drug should be used during pregnancy only when clearly needed.
Because Piperacillin is distributed into milk in low concentrations and because it is not known whether Tazobactam is distributed into milk, Piperacillin/Tazobactam should be used with caution in nursing women.
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